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Model Experiment of Benign Paroxysmal Positional Vertigo
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Sung Huhn Kim
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Res Vestib Sci. 2013;12(2):39-46.
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 Abstract
- Benign paroxysmal positional vertigo (BPPV) is a most common cause of vertigo. Although endolymphatic flow which is caused by movement of detached-otoconia from otolithic organs has been suggested as a cause of positional vertigo, none has proved it in the human inner ear. Therefore, there were many trials to explain the anatomical characteristics of cupula, physiology of cupula deviation, pathologic mechanisms of BPPV, and clinical characteristics of BPPV using animal membranous labyrinth. In this review, results of basic animal experimental studies to understand anatomical structures and pathological mechanisms related to BPPV are introduced. In addition, future directions for experimental studies to elucidate the mechanism of BPPV will be suggested.
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A Case of Otosclerosis with Meniere’s Symptom
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Dong Woo Hyun, Se Ra Park, Sung Huhn Kim, Won Sang Lee
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Res Vestib Sci. 2009;8(2):174-177.
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Abstract
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- It has been postulated that otosclerosis may produce vertigo by several mechanisms. An association between otosclerosis and Meniere’s disease has been proposed on both a clinical and histopathologic basis but the causal relationship is controversial. We report a case of bilateral otosclerosis in a man manifesting vertiginous symptoms. Fifty one year-old man was examined for rotational vertigo and poor hearing in his both ear for ten years. The audiogram revealed left sided hearing loss of a conductive type and right sided sensorineural hearing loss, and caloric asymmetry. Meniere’s disease was suspected, but temporal bone CT showed low attenuated lesion around bilateral cochlear and semicircular canal. A diagnosis of otosclerosis was made. He was recommended sodium fluoride therapy. Severe endolymphatic hydrops manifesting itself as Meniere’s disease can be the result of otosclerosis, so vertiginous and concurrent hearing symptoms should not be overlooked.
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Effect of Intratympanic Chemical Labyrinthectomy with Streptomycin on Auditory Symptoms
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Hyun Su Kim, Sung Huhn Kim, Dae Bo Shim, Sang Cheol Kim, Won Sun Yang
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Res Vestib Sci. 2009;8(1):32-36.
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Abstract
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- Background and Objectives Background and Objectives: Intratympanic treatment with aminoglycosides for Ménière’s disease has been used, trying to eliminate vertigo complaints, while preserving hearing. This study was undertaken to evaluate the therapeutic outcomes for auditory symptoms in Ménière’s disease patients after intratympanic application with single low-dose streptomycin powder.
Materials and Methods Ninty-eight patients diagnosed with definite Ménière’s disease who underwent chemical labyrinthectomy with streptomycin at Yonsei University Medical Center from March 1997 to June 2006 were enrolled. Low dose streptomycin powder (10 mg) was applied into the round window niche directly. Changes of hearing threshold, tinnitus and aural fullness were evaluated postoperatively according to Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Ménière’s disease of American Academy of Otolaryngology–Head and Neck Surgery.
Results Hearing threshold was not changed significantly after the procedure (from 65.5±19.1 to 69.3±20.0 p>0.05) and was improved in 7% of the patients. Hearing deterioration after the procedure was detected only in 17%. Tinnitus and aural fullness was improved in 51% and 25% respectively.
Conclusion Single application of streptomycin powder filling round window niche showed minimal deterioration of hearing threshold. It is the useful method to improve or prevent the progress of auditory symptoms in patients with Ménière’s disease.
Key Words: Streptomycin; Hearing loss; Tinnitus; Meniere Disease; Aural fullness
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